Friday, March 15, 2013

Thinking About A Home Improvement Project? Read This Advice ...

You must know what you?re doing before starting any home improvement projects. The piece below is meant to give you the facts you need as you embark on your home improvement journey. The information you?re about to read are going to help you get the experience you need.

Does your lawn have bare spots without grass? If that is the case, consider purchasing some grass seed. A lawn that looks even can truly improve your yard. Get your yard back to its original luster as soon as possible.

Don?t make the mistake of not sealing your grout after you put down tile. Grout is not waterproof on its own, but porous instead. When it isn?t sealed, it can become moldy. Unsealed grout also stains easily. Not only is sealed grout easier to clean and more attractive, it may save you a lot of money by preventing expensive-to-repair mildew issues.

It is a good idea to do home improvements soon after you notice there is an issue. In many cases, when you first notice damage, it?s minor enough that you can just forget about it and keep living with it. This is a temptation that you have to resist. Your home?s systems are all connected together. Damage to one system can quickly spread to all of them. A tiny problem can eventually become a huge one if left to fester.

Take time to investigate the background of any company you wish to do business with to ensure that they are above-board. Look for a real address and in-person meetings. Select companies that have great reputations.

If you have problems finding the grout color you need, you can tint your own. You can find cheap acrylic craft paint at many stores. Experiment with a small amount of dry grout. Use paint instead of water when you mix it, spread it on a paper plate and allow it to dry. This is a fast way to find the perfect grout shade.

Before you begin demolishing, do a little research. It can seem exciting and easy to just rip into your demolition work with gusto. Look for electrical wires before you begin, though. Prepare well to make sure you don?t try taking down a wall that will be cost-prohibitive to replace.

To start the process of installing new cabinets in your kitchen, draw a benchmark line horizontally across the kitchen?s perimeter. Use this as a reference point so that you can measure properly. This line should start at the floors highest point.

A good home improvement tip is to make sure the company you?re doing business with is legit. If they only want to speak over the phone and will not give you an actual address, they are probably not reliable. Try to go with companies that have a strong reputation.

Make sure you put a covering on the floor before you paint. It can be hard to clean paint from hardwood or carpeted floors. Accidents can be avoided by laying old linens, drop cloths or blankets on the floor to catch paint drips.

If you?re purchasing materials for a home improvement project, be sure you don?t forget to buy safety equipment. Include gloves, safety glasses, hard hats, and steel-toed boots as necessary. You will lose a lot of time if you hurt yourself and could even injure yourself badly enough to miss work. Wear the equipment throughout the project.

Home improvement isn?t necessarily hard. Once you know the basics, virtually any project will be easier to complete, whether it?s simple or complex. Just remember what you?ve learned from this article, and soon, your home will be looking better than ever.

Source: http://www.casapayo.com/uncategorized/thinking-about-a-home-improvement-project-read-this-advice-first/

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Early apps for touch-based Ubuntu reveal a mostly clean aesthetic

Early apps for touchbased Ubuntu reveal a mostly clean aesthetic

The clatter of ergonomic keyboards is already bearing fruit, just two months after the Ubuntu developer community was let loose on the SDK for the newly touch-enabled OS. Canonical's Michael Hall has posted an update on his personal blog detailing progress with some core apps, such as Calendar and Weather, as as well the broader effort to give mobile Ubuntu a sense of personality. The source link shows off some nice-looking puzzle games, news readers and even an app built around the disembodied head of a strapping lad called Jono, who in many ways symbolizes the minimal-but-cheerful look of the emerging ecosystem. A bit of debugging here, a swoosh of the razor there, and it could be perfect.

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Source: Michael Hall's blog

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/SW6aCLVVCLs/

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Thursday, March 14, 2013

Ancient Mars could have been habitable, says NASA

A Martian rock sample collected by NASA's Curiosity rover suggests that the Red Planet could have supported living microbes in its ancient past, says NASA.

By Mike Wall,?SPACE.com / March 12, 2013

This image from NASA's Curiosity rover shows the first sample of powdered rock extracted by the rover's drill. The image was obtained by Curiosity's Mast Camera on Feb. 20.

NASA/JPL-Caltech/MSSS

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It's official: Primitive life could have lived on ancient Mars, NASA says.

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A sample of Mars drilled from a rock by NASA's?Curiosity rover?and then studied by onboard instruments "shows ancient Mars could have supported living microbes," NASA officials announced today (March 12) in a statement and press conference.

The discovery comes just seven months after the Curiosity rover landed on Mars to spend at least two years determining if the planet could have ever supported primitive life.

"A fundamental question for this mission is whether Mars could have supported a habitable environment," said Michael Meyer, lead scientist for NASA's Mars Exploration Program at the agency's headquarters in Washington. "From what we know now, the answer is yes." [The Search for Life on Mars (Photo Timeline)]

Curiosity drilled into a rock?on Feb. 8, boring 2.5 inches (6.4 centimeters) into an outcrop called John Klein using its arm-mounted hammering drill, going deeper than any robot had ever dug into the Red Planet before.??Two weeks later, the rover transferred the resulting gray powder samples into two onboard instruments called Chemistry and Mineralogy (CheMin) and Sample Analysis at Mars, or SAM.

CheMin and SAM identified some of the key chemical ingredients for life in this powder, including sulfur, nitrogen, hydrogen, oxygen, phosphorus and carbon. The fine-grained John Klein rock also contains clay minerals, suggesting a long-ago aqueous environment that was salty and neutral, researchers said ? that is to say, a place that likely was habitable.

Analysis of the samples was complicated by a computer glitch that's still affecting Curiosity today.

In late February, Curiosity's handlers determined that a glitch had affected the flash memory on the rover's main, or A-side, computer system. So they swapped the rover over to its backup (B-side) computer, which caused the robot to go into a protective "safe mode" on Feb. 28.

Curiosity emerged from this safe mode on March 2, only to be put on standby briefly once again a few days later to wait out a Mars-bound solar eruption. Full science operations have yet to resume, but Curiosity's B-side computer is working well as engineers continue to work through the mysterious problem with the A-side, team members said.

"These tests have provided us with a great deal of information about the rover's A-side memory," Jim Erickson, Curiosity deputy project manager at NASA's Jet Propulsion Laboratory in Pasadena, Calif., said in a statement. "We have been able to store new data in many of the memory locations previously affected and believe more runs will demonstrate more memory is available."

Engineers plan to upload two software patches later this week, then reassess when full mission operations can resume, officials said.

Curiosity landed inside Mars' huge Gale Crater onAug. 5, kicking off a two-year prime surface mission to determine if the?Red Planet has ever been able to support microbial life. ?CheMin and SAM are two of the 10 instruments it carries to aid this quest.

While Curiosity has already made a number of interesting discoveries near its landing site ? including an ancient streambed where water likely flowed continuously for thousands of years ? its main destination is a set of interesting deposits at the base of Mount Sharp, which rises 3 miles (5 kilometers) from Gale's Center.

Follow Mike Wall on Twitter?@michaeldwall.?Follow us?@Spacedotcom,?Facebook?or?Google+. Originally published on?SPACE.com.

Copyright 2013?SPACE.com, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://rss.csmonitor.com/~r/feeds/science/~3/M7PTuDGVYD8/Ancient-Mars-could-have-been-habitable-says-NASA

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Key step in manufacture of red blood cells decoded: Subtle regulatory chords that direct the birth of blood cells discovered

Mar. 14, 2013 ? A healthy adult must generate as many as one hundred billion new red blood cells each day, to maintain the numbers circulating in his blood. A team of EPFL researchers has identified a key step in the process by which red blood cells are born. The discovery could not only shed light on the causes of blood disorders such as anemia, it could also bring closer the medics' dream of being able to manufacture red blood cells in the lab -- thus providing a potentially inexhaustible supply of an essential component of blood for transfusion.

A red blood cell, or erythrocyte, is essentially a sack of haemoglobin that transports oxygen around the body. It starts life in the bone marrow as a haematopoietic stem cell, and undergoes a highly controlled process of proliferation and differentiation before acquiring its final identity.

One key step in that differentiation process is mitophagy, the elimination by absorption of the stem cell's respiratory apparatus, mitochondria. With the mitochondria gone, the cell's carrying capacity for haemoglobin is maximised. But the mechanism controlling mitophagy has never been properly understood, until now.

In a paper published this week in Science, Isabelle Barde of the EPFL's School of Life Sciences and Frontiers in Genetic Programme, and colleagues, describe experiments which show that KRAB-containing zinc finger proteins, working in concert with a cofactor called KAP1, modulate mitophagy in subtle and sophisticated ways.

The senior author on the paper, virologist Didier Trono, has been interested in the KRAB/KAP1 system for several years. 350 million years old, it is known to have a role in "silencing" components of the mammalian genome known as retroelements, because they were originally retroviruses that became incorporated into the genetic code of the organisms they infected. "It did such a good job that over the course of evolution it got co-opted to do many other things," Trono says.

Among the roles the KRAB/KAP1 system took on was regulating mitophagy. The researchers found that mice genetically modified to lack KAP1 quickly became anemic because they were unable to make red blood cells. More specifically, they found, the process of stem cell differentiation stalled at the stage where mitochondria were degraded in erythroblasts, the precursors of erythrocytes. And knocking out KAP1 had a similar effect in human blood cells, indicating that its role in regulating mitophagy has been conserved throughout evolution, from mouse to man.

The researchers went on to show that the KRAB/KAP1 system works by repressing repressors of mitophagy. In other words, like any good double negative, it activates the target process. That suggests that mutations in the various components of this regulatory system could contribute to blood disorders such as anemia and certain types of leukemia, which in turn indicates future therapeutic targets for those diseases. It also suggests ways in which red blood cell synthesis might be emulated in the lab.

But the finding has broader significance too. Mitochondria, while essential for the healthy functioning of many cells, can also be lethal to cells if they generate damaging free radicals -- by-products of cellular respiration under certain conditions. The oxidative stress these free radicals produce has been implicated in liver disease, heart attacks and obesity. Hence, understanding how mitophagy is controlled could lead to a better understanding, and potentially better treatment, of those conditions.

Trono thinks that the principle of multilayered and combinatorial regulation may apply to a wide range of physiological systems. "It gives a tremendous level of modularity to nature to accomplish physiological events," he says, likening it to the way in which a pipe organ works.

An organist has both a keyboard and a pedalboard at his disposal, and he uses them in multifarious combinations to modulate the sound his instrument produces. Similarly, tiny adjustments in one or a few controlling elements can produce significant effects in many biological processes. And though mutations in any one of them could potentially lead to malfunction, the damage tends to be limited because the contribution of each one is small. That, in turn, renders the system robust. It's that robustness, Trono believes, that evolution has been selecting and refining for hundreds of millions of years.

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The above story is reprinted from materials provided by Ecole Polytechnique F?d?rale de Lausanne, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Isabelle Barde, Benjamin Rauwel, Ray Marcel Marin-Florez, Andrea Corsinotti, Elisa Laurenti, Sonia Verp, Sandra Offner, Julien Marquis, Adamandia Kapopoulou, Jiri Vanicek, and Didier Trono. A KRAB/KAP1-miRNA Cascade Regulates Erythropoiesis Through Stage-Specific Control of Mitophagy. Science, 14 March 2013 DOI: 10.1126/science.1232398

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/UubqsprnlLs/130314144348.htm

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Wednesday, March 13, 2013

Video: Review: 'God of War: Ascension' is short of greatness

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Source: http://www.nbcnews.com/video/in-game/51154149/

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PFT: Kruger to join Browns for $8-9M per season

Tennessee Titans v Buffalo BillsGetty Images

The Ryan Fitzpatrick era is over, and Buffalo needs a new quarterback.

The Bills have announced that they cut Ryan Fitzpatrick today, on the first day of the new league year.

Cutting Fitzpatrick isn?t a big surprise, considering that the Bills owed him a $3 million roster bonus if he was still on the team tomorrow, and that Bills G.M. Buddy Nix was surreptitiously taped talking about, among other things, his frustration that the quarterback was holding the team back.

The six-year, $59 million contract extension Fitzpatrick signed in October of 2011 turned out to be an expensive mistake ? and a reminder that sometimes in the NFL, ?six-year contracts? last less than a year and a half. If the Bills give this move a post-June 1 designation, Fitpatrick?s cap hit would be $3 million this year and $7 million in 2014.

Now the question is where the Bills will look for their next starting quarterback. This isn?t viewed as a great year to draft one, but the Bills may decide to spend their first-round draft pick on a passer they hope will be their franchise quarterback.

And the question for Fitzpatrick is whether any team wants him. If any team does, it will likely be as a backup ? and will definitely be for a lot less money than the Bills paid him.

Source: http://profootballtalk.nbcsports.com/2013/03/12/kruger-will-strike-it-richf-in-cleveland/related/

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Tuesday, March 12, 2013

Black smoke from chapel chimney: No pope yet

People watch on a video monitor in St. Peter's Square as Monsignor Guido Marini, master of liturgical ceremonies, closes the double doors to the Sistine Chapel in Vatican City Tuesday, March 12, 2013, at the start of the conclave of cardinals to elect the next pope. Marini closed the doors after shouting "Extra omnes," Latin for "all out," telling everyone but those taking part in the conclave to leave the frescoed hall. He then locked it. (AP Photo/Michael Sohn)

People watch on a video monitor in St. Peter's Square as Monsignor Guido Marini, master of liturgical ceremonies, closes the double doors to the Sistine Chapel in Vatican City Tuesday, March 12, 2013, at the start of the conclave of cardinals to elect the next pope. Marini closed the doors after shouting "Extra omnes," Latin for "all out," telling everyone but those taking part in the conclave to leave the frescoed hall. He then locked it. (AP Photo/Michael Sohn)

Black smoke emerges from the chimney on the roof of the Sistine Chapel, in St. Peter's Square at the Vatican, Tuesday, March 12, 2013. The black smoke indicates that the cardinals did not elect a new pope. (AP Photo/Dmitry Lovetsky)

In this image taken from video provided by Vatican TV, cardinals line up to place their hands on the Gospel to "promise pledge and swear" to keep the oath of secrecy before taking their seats for the conclave to elect the next pope inside the Sistine Chapel in Vatican City Tuesday, March 12, 2013. (AP Photo/Vatican TV)

In this image made from video provided by Vatican CTV television, Nigerian Cardinal Peter Kodwo Appiah Turkson, right, takes an oath of secrecy inside the Sistine Chapel, at the Vatican, Tuesday, March 12, 2013, before the start of the conclave to elect the 266th Roman Catholic Church pope. (AP Photo/CTV via APTV)

In this image made from video provided by Vatican CTV television, US Cardinal Sean Patrick O'Malley, right, takes an oath of secrecy inside the Sistine Chapel, at the Vatican, Tuesday, March 12, 2013, before the start of the conclave to elect the 266th Roman Catholic Church pope. Behind O'Malley are Cardinals Stanislaw Dziwisz, of Poland, Carlo Caffara, of Italy, Sean Baptist Brady, of Ireland, and Lluis Martinez Sistach, of Spain. (AP Photo/CTV via APTV)

(AP) ? This time there was no doubt. There was no new pope yet, and the mystery of who ? and when ? was as thick as the unmistakable heavy black smoke billowing from the Sistine Chapel chimney.

As thousands waited in a cold night rain in St. Peter's Square, the cardinals signaled Tuesday they had failed on their first attempt to find a leader for the world's 1.2 billion Catholics and their troubled church.

"It's black, it's black, it's waaay black!" screamed Eliza Nagle, a 21-year-old Notre Dame theology major on an exchange program in Rome, as the smoke poured from the 6-foot-high copper chimney at 7:41 p.m.

"They definitely got the color right this time," agreed Father Andrew Gawrych, an American priest based in Rome, referring to the confusion over the smoke during the 2005 conclave that elected Pope Benedict XVI.

That was thanks to special smoke flares ? akin to those used in soccer matches or protests ? lit in the chapel ovens to make the burned ballots black, the sign that cardinals must come back for another day of voting Wednesday.

Tuesday's drama unfolded against the backdrop of the turmoil unleashed by Benedict's surprise resignation and the exposure of deep divisions among cardinals grappling with whether they need a manager to clean up the Vatican's dysfunctional bureaucracy or a pastor who can inspire Catholics at a time of waning faith and growing secularism.

Surrounded by Michelangelo's imposing frescoes portraying the beginning and the end of the world, cardinals locked themselves into the Sistine Chapel following a final appeal for unity by their dean and set about the business of electing the 266th pope.

The 115 scarlet-robed prelates chanted the Litany of Saints, the sounds of the Gregorian chant echoing through the soaring hall as, walking two-by-two, they implored the saints to guide their voting. They then took an oath of secrecy, first collectively and then individually, as each placed his right hand on the gospel and intoned the words in Latin accented by their native languages ? English, German, French, Italian, Arabic and so on.

Then the master of liturgical ceremonies intoned the words "Extra omnes" ? "everyone out" ? and dozens of prelates and Vatican officials departed as the chapel's heavy, ornately carved wooden doors swung shut.

The cardinals then proceeded with the carefully choreographed vote, each writing his choice on a piece of paper, then folding it and tipping it into an urn, to be counted by hand by three "scrutineers" who read out the results, one by one.

With no cardinal winning the required 77 votes on the first ballot, the cardinals returned to the Vatican hotel for a simple dinner of pasta with tomato sauce, soup and vegetables before another day of voting Wednesday.

Benedict's surprise resignation has thrown the church into turmoil and exposed deep divisions between Vatican-based cardinals and those in the field who have complained about Rome's inefficiencies and indifference to their needs.

The leading contenders for pope have fallen into two camps, with Italian Cardinal Angelo Scola, the archbishop of Milan, seen as favored by those hoping to shake up the powerful Vatican bureaucracy, and Brazilian Cardinal Odilo Scherer favored by Vatican-based insiders who have defended the status quo.

Other names include Canadian Cardinal Marc Ouellet, who heads the Vatican's powerful office for bishops and U.S. cardinals Timothy Dolan, the exuberant archbishop of New York, and Sean O'Malley, the archbishop of Boston.

In a final appeal before the conclave began, the dean of the College of Cardinals, retired Cardinal Angelo Sodano, used his homily at a morning Mass in St. Peter's Basilica to urge unity. He asked that cardinals put their differences aside for the good of the church and the future pope.

"Each of us is therefore called to cooperate with the successor of Peter, the visible foundation of such an ecclesial unity," Sodano said.

He was interrupted by applause from the public in the pews ? not so much from the cardinals ? when he referred to the "beloved and venerated" Benedict XVI and his "brilliant" pontificate.

Sitting in the front row was Benedict's long-time aide, Archbishop Georg Gaenswein, who reported that the now-emeritus pope was watching the proceedings from his residence in Castel Gandolfo, 17 miles away, according to Vatican spokesman Rev. Thomas Rosica.

For more than a week, the cardinals have met privately to try to figure out who among them has the stuff to be pope and what his priorities should be. But they ended the debate with questions still unanswered, and many cardinals predicting a drawn-out election that will further expose the church's divisions. The conclave proceeds in silence, with no formal debate, behind closed doors.

During discussions before the conclave, Vatican-based cardinals defended their administration against complaints that they have been unresponsive to diocesan needs, according to leaks of the proceedings in the Italian media. At one point on Monday, the Brazilian head of one Vatican office reportedly drew applause for challenging the Vatican No. 2, who has been blamed for most of the bureaucracy's administrative failings.

"Let us pray for the cardinals who are to elect the Roman pontiff," read one of the prayers during the Mass. "May the Lord fill them with his Holy Spirit, with understanding and good counsel, wisdom and discernment."

In his final radio address Tuesday before being sequestered, Dolan said a certain calm had taken hold, as if "this gentle Roman rain is a sign of the grace of the Holy Spirit coming upon us."

"And there's a sense of resignation and conformity with God's plan. It's magnificent," he said during his regular radio program on SiriusXM's Catholic Channel.

Outside, the faithful gathered to await the outcome, with groups of nuns singing and playing the guitar, cheering the cardinals on.

"I don't expect any quick fixes. There will always be problems," said Sister Manaoag, a nun from the Philippines. "We have to not get stuck with seeing things like factions and problems, but see beyond that. What does God want? This is something we sometimes forget."

Other pilgrims acknowledged the challenges facing the church.

"It's a moment of crisis for the church, so we have to show support of the new pope," said Veronica Herrera, a real estate agent from Mexico who traveled to Rome for the conclave with her husband and daughter.

Yet the mood was not entirely somber.

A group of women who say they are priests launched pink smoke from a balcony overlooking the square to demand female ordination ? a play on the famous smoke signals that will tell the world whether a pope has been elected. Two topless activists from Femen, a Ukrainian feminist group, were dragged away by police. Femen activists have previously protested the Vatican's opposition to gay marriage.

And in a bizarre twist, basketball star Dennis Rodman promised to be in St. Peter's Square on Wednesday in a makeshift popemobile as he campaigns for Cardinal Peter Turkson of Ghana to become the first black pope.

None of the cardinals will see it, since they will be sequestered inside the Vatican walls. They are allowed to travel only from the Vatican hotel through the gardens to the Sistine Chapel and back until they have elected a pope. No telephones, no newspapers, no television, no tweeting.

The focus of the ritual is on the Sistine Chapel, the Michelangelo masterwork painted over the course of nearly 30 years starting in 1508, and so astonishing to Pope John Paul II that he called it "the sanctuary of the theology of the body."

The most famous frescoes are "Creation," a series of nine paintings running the length of the ceiling, the most well-known of which is the "Creation of Adam," showing God and Adam, their fingers reaching out to one another. "The Last Judgment" behind the altar depicts a muscular Jesus surrounded by naked masses, some ascending to heaven and others falling to hell.

Benedict once wrote that the images of the beginning and the end of creation weighed on him when, as then Cardinal Joseph Ratzinger, he was an elector in the 1978 conclave that brought John Paul II to the papacy.

"I know well how we were exposed to those images in the hour of the important decisions, how they challenged us and how they instilled in our souls the greatness of our responsibility," Ratzinger said in 2003, at the presentation of a book of poetry by John Paul about the Sistine frescoes.

That burden, coupled with so much uncertainty and upheaval going into the conclave, led the American cardinals to disagree on whether to expect a short or long conclave.

Cardinal Dolan this week publicly expressed optimism that the election would be wrapped up quickly. And on the eve of the conclave, he wrote a letter to New York priests, saying: "My guess is that we'd have a new Successor of St. Peter by Thursday evening," according to Dolan's spokesman, Joseph Zwilling.

That bullish stance stood in stark contrast with the view of Chicago Cardinal Francis George.

His spokeswoman, Colleen Dolan, told The Associated Press that the cardinal suggested it could be a long affair, raising the possibility that the electors may still be meeting by Saturday, when conclave rules require them to take a break and spend some time in prayer before resuming voting.

Another American had something else entirely on his mind. On the day of the conclave, the archdiocese of Los Angeles agreed to pay nearly $10 million to settle four clergy sex abuse cases that alleged abuse by a now-defrocked priest who told Cardinal Roger Mahony nearly 30 years ago that he had molested children.

Mahony ignored a petition urging him to recuse himself from the conclave because of how he covered up for abusive priests and is taking part in the voting.

___

Rachel Zoll, Karl Ritter, Frances D'Emilio and Daniela Petroff contributed.

___

Follow Nicole Winfield at www.twitter.com/nwinfield

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-03-12-EU-Vatican-Pope/id-949d79e57a3349e0ae6df95d583eb5ec

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