Sunday, February 3, 2013

Love your Friends - Steve Nash Fitness World & Sports Club

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This month don?t just walk towards your fitness goals?. run, jump, and train your way there with the latest gear from New Balance. You made it through January and we want to reward you for all your hard work and dedication. This month if you burn 8 or more sessions of Personal Training we are going to give you a $50 gift card to New Balance.
Looking to ramp up your fitness revolution? We want to help you with that too. Achieve your fitness goals faster with the help of a Personal Trainer. Our certified Personal trainers will design a custom health and fitness plan that works for you and your lifestyle. With their guidance and support you will you be on the fastrack to your fittest self. This month, first time clients buying 12 or more personal training sessions will receive a $100 New Balance gift card, buy 24 or more sessions and we will give $150.

Train hard this February and let us spoil you with the latest gear from New Balance.

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Source: http://www.snclubs.com/blog/2013/02/love-your-friends/

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Saturday, February 2, 2013

Rising beef prices threaten $1 McDouble

McDonald's popular $1 McDouble cheeseburger, which has lured customers to the Golden Arches since 2008, is getting hard to sustain as rising beef prices threaten the company's profit margin.?

The world's biggest restaurant chain launched a competing $1 Grilled Onion Cheddar Burger in December. It also made the new sandwich - with one beef patty rather than the McDouble's two - a star of current television commercials, a status it shares with the McDouble.?

The dilemma for McDonald's Corp restaurant operators is that the McDouble has the highest ingredient costs on the Dollar Menu, making it a bad financial proposition unless customers add high-margin sides such as french fries or soda.?

"If the McDouble is all the customer buys, you lose money," said Richard Adams, a former franchisee who now advises the chain's restaurant operators. "Depending on what happens to beef prices, McDonald's management should be open to taking the McDouble off the Dollar Menu."?

The decision would be a significant one. McDonald's gets 10 to 15 percent of its sales from the Dollar Menu and experts say the McDouble is one of the most popular items on it.?

Many franchisees, who pay royalties to the parent company based on overall sales, have exercised their option to move the McDouble off the Dollar Menu by raising its price over $1.?

Reuters' checks of McDonald's restaurants in more than a dozen U.S. cities found that franchisees sell the McDouble for $1.09 in San Francisco, $1.19 in Los Angeles, $1.80 in Kodiak, Alaska and $1.89 in New York City.?

The McDouble was not even offered on menus at restaurants Reuters visited in Chicago and Boston, but was available on request for $1.29 and $1.49, respectively. It remains on the Dollar Menu in cities such as Phoenix, Fresno, Denver, Seattle, St. Louis and Washington, DC.?

McDonald's is "committed to the Dollar Menu and the McDouble, and both are strongly supported by the majority of our franchisees," spokeswoman Danya Proud said in a statement. "To comment on future national changes would be inaccurate and speculative."?

The Dollar Menu food and marketing changes are part of McDonald's plan to stop two consecutive years of margin declines at its 14,000 U.S. restaurants. They come as new McDonald's Chief Executive Don Thompson sharpens the company's focus on its famed Dollar Menu to lure cash-crunched diners and fend off resurgent rivals such as Yum Brands Inc's Taco Bell chain and Burger King Worldwide Inc .?

They also hint at strategies that U.S. restaurants could use to contain the damage from higher beef costs. McDonald's has a history of shaking up the Dollar Menu lineup in response to food cost spikes.?

In December 2008, the company raised the price of its flagship Double Cheeseburger to $1.19 from $1 and handed its Dollar Menu slot to the McDouble, which is essentially a Double Cheeseburger minus one slice of cheese.?

That coincided with U.S. wholesale food price increases of 7.6 percent in 2007 and 7.7 percent in 2008.?

McDonald's moved again in March 2012 after wholesale food prices spiked, replacing the Dollar Menu's small drinks and small french fries with fresh baked cookies and ice cream cones. At the same time, it debuted a new "Extra Value Menu" category for items priced between $1 and $2.?

Competing hamburger chains stole a page from McDonald's and shuffled their value menu lineups. Burger King quickly followed McDonald's with similar moves and Wendy's Co. plans to replace its 99-cent menu with a 99-cent to $1.99 "Right Price Right Size Menu."?

Beef prices are expected to rise above recent highs and to stay high for at least the next two years as the effects of last summer's historic U.S. drought ripple through the food system, said Jim Robb, an economist at the Livestock Marketing Information Center.?

Ground beef prices already are up 6 percent to 8 percent so far this year, said John Davie, CEO of Consolidated Concepts, a firm that helps restaurants negotiate purchases.?

To be sure, McDonald's is known for using its massive size to squeeze better prices out of suppliers. The company forecast commodity inflation of just 1.5 percent to 2.5 percent this year for its U.S. business, far less than the National Restaurant Association's expectation for 2013 wholesale food price inflation in the low 4 percent range.?

But analysts are skeptical that McDonald's can control rising prices as well as it thinks, meaning there could be even more pressure on the McDouble's bottom line.?

"It's possible that they hit it, but I would say the odds are low that they hit it," Hedgeye Risk Management analyst Howard Penney said of McDonald's and its commodity cost forecast.?

He expected the company to raise that view at some point this year.?

Additional reporting by Michael Hirtzer and Theopolis Waters in Chicago, Ross Kerber in Boston, Phil Wahba in New York, Keith Coffman in Denver, Corrie MacLaggan in Austin, Stephen Keleher in Fresno, Lisa Dembiczak in Seattle, Ayesha Rascoe in Washington, Edwin Chan in San Francisco, Yereth Rosen in Anchorage, David Schwartz in Phoenix.

Copyright 2013 Thomson Reuters.

Source: http://www.nbcnews.com/business/rising-beef-prices-threaten-1-mcdouble-1B8211205

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RESTAURANTS AND FOOD IN CORK: Food and Drinking Spotting

Food and Drink Spotting

L?Atitude 51?

L?Atitude 51 (No 1 Union Quay) have a Whisky Tasting session?on Thursday 7th of February at 7.30pm in their Wine Workshop upstairs. A 90-minute fun and interactive tutored tasting of 7 different whiskies from the world?s major whisky-production regions where you?ll learn to taste like a pro and explore the subtle and stark differences between whiskies.

Price: ?30pp ? includes 7 drams of different whiskies and their signature canap?s. Booking required as spaces are limited. You can phone on 021 239 0219.

Liberty Grill

?Feeling a bit nostalgic for the old DINE IN CORK promotion, so for a limited time, we would like to offer you any appetizer, any one of the seasonal specials plus any dessert with a tea or coffee to finish for ?25.? Check their menu here.?

Fermoy Indoor Market & Baby Fair

Fermoy Indoor Market & Baby Fair?is fully booked for Sunday next 3rd February. A mega jam packed market hall comprising of the following - Milly?s Attic, Monagown Preserves, The Gift Basket, Avon Killeagh, Artwork by Maria Dowling, Ellen's Sewing Basket, Marys Baby Cardigans, Geeya's Cakes, Margaret's Dolls Houses, Costume Jewellery, personalised baby items, Cork Usbourne Books, Laura's Kids Chairs, Cupcakes by Siobhain, Silverhaven Jewellery, Bnbump Creations, Fantasy Face Painting, Beauty care products, Deisuin Candles, tea & coffee n toastie shop and so much more...

New to the Fermoy Indoor Market is a relaxing kiddie Area with soft mats, a selection of toys for the younger ones, kiddie table & chairs to draw or colour. Our new Face painter is Jenifer who will be there to develop their creativity.

Spinning Wheel Restaurant

On Friday, Feb 1st, it is Fiver Friday in the Spinning Wheel Restaurant at Griffin?s Garden Centre. A Gourmet Main Course for ?5. Definitely one of the best Lunch Deals in Cork. Lunch served from 12:30 and while stocks last. Also Margaret will be giving a demonstration on the Tradition of the St Brigid's Cross at 12 noon. Also, from Monday 4th of Feb, the Spinning Wheel Restaurant will be serving Afternoon Tea Daily from 3:00- 5:30.

Shorts

Foll?in Preserves ?@FollainJams

? #EatWell4Life pic.twitter.com/AdVayg6b


Source: http://www.corkbilly.com/2013/02/food-and-drinking-spotting.html

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New study sheds light on link between dairy intake and bone health

Feb. 1, 2013 ? A study by researchers at the Institute for Aging Research (IFAR) at Hebrew SeniorLife, an affiliate of Harvard Medical School (HMS), has found that dairy intake -- specifically milk and yogurt -- is associated with higher bone mineral density (BMD) in the hip, but not the spine. Cream, on the other hand, may be associated with lower BMD overall. Published February 1 in the journal Archives of Osteoporosis, these findings suggest that not all dairy products are equally beneficial in promoting bone strength.

"Dairy foods provide several important nutrients that are beneficial for bone health," says lead author Shivani Sahni, Ph.D., Musculoskeletal Research Team, IFAR. "However, cream and its products such as ice cream have lower levels of these nutrients and have higher levels of fat and sugar. In this study, 2.5 -- 3 servings of milk and yogurt intake per day were associated with better bone density. More research is needed to examine the role of cheese intake (some of which can be high in fat and sodium), and whether individual dairy foods have a significant impact in reducing fractures."

IFAR researchers based their findings on data collected from a food frequency questionnaire completed by 3,212 participants from the Framingham Offspring study. They then compared participants' dairy intake with BMD measurement, which revealed the benefits of milk and yogurt versus cream in largely middle-aged men and women. According to the study, nutrient composition varies among dairy foods. Choosing low-fat milk or yogurt over cream can increase intake of protein, calcium and vitamin D while limiting intake of saturated fats.

This study is an example of a growing area of research focused on the relationship between nutrition and bone health. Past studies suggest that dairy products contain more than one beneficial nutrient, and for this reason certain dairy products may contribute towards maintaining healthier bones.

Research like this supports the idea that proper nutrition can help combat osteoporosis and fractures. Osteoporosis is considered a major public health threat for an estimated 44 million Americans, or half of those aged 50 and older.

? An estimated 10 million in the U.S. already have the disease. Women are at higher risk than men.

? Another 34 million Americans have low bone density, putting them at increased risk for osteoporosis and fractures, especially of the hip, spine and wrist. About one-quarter of those who suffer a hip fracture die within a year of the injury.

? Osteoporosis-related fractures were responsible for an estimated $19 billion in health care costs in 2005, with that figure expected to increase to $25 billion by 2025.

Co-authors on the study include, Katherine L. Tucker, Ph.D.; Douglas P. Kiel, M.D., M.P.H.; Lien Quach, M.P.H, M.S.; Virginia A. Casey, Ph.D.; Marian T. Hannan, D.Sc., M.P.H.

This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR # 053205 and also AR/AG41398) and by the National Heart Lung and Blood Institute's Framingham Heart Study (N01-HC-25195), the Melvin First Young Investigator Award and General Mills Bell Institute of Health and Nutrition.

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Story Source:

The above story is reprinted from materials provided by Hebrew SeniorLife Institute for Aging Research.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Shivani Sahni, Katherine L. Tucker, Douglas P. Kiel, Lien Quach, Virginia A. Casey, Marian T. Hannan. Milk and yogurt consumption are linked with higher bone mineral density but not with hip fracture: the Framingham Offspring Study. Archives of Osteoporosis, 2013; 8 (1-2) DOI: 10.1007/s11657-013-0119-2

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/nutrition/~3/dAJpGOcggcg/130201132336.htm

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Friday, February 1, 2013

Boy snatched from school bus remains hostage

A school bus driver was fatally shot in Midland County, Ala., by a man who boarded the bus with children on board and then abducted a six-year-old student. He is holding the child hostage in an underground bunker. WSFA's Samuel King reports.

By Erin McClam and Matthew DeLuca, NBC News

A boy was still being held captive in an underground bunker by a man described as a survivalist early Thursday, as authorities sought to end a hostage situation in southern Alabama that has already spanned 36 hours.?

The man kidnapped the boy on Tuesday afternoon after he stormed a school bus and demanded the bus driver hand over young children. When the driver refused, the suspect fatally shot him and grabbed the boy, who is 5 or 6. ?

The child is said to be "okay", having been given access to medicine and?the box of crayons and a coloring book he requested, according to WSFA-TV reporter Samuel King.?

Concerned citizens attended?vigils at several local churches Wednesday night, lighting candles and praying for the boy's safe release, WSFA reported.

"Right now the whole town seems like they're just in a mourning stage," convenience store?manager Carl McKenzie told the station. "I would go take that child's place if I could, just to get him out of danger." ??

At a press conference Wednesday evening, Dale County Sheriff Wally Olson said authorities "have no reason to believe the child has been harmed."

A disturbing picture has emerged of the suspect, who a source close to the investigation identified to NBC News as Jimmy Lee Dykes, 65. The source said he was a loner and survivalist who ?does not trust the government? and holds ?anti-American views.?

Read more: Hostage suspect was loner, missed court appearance

People in the remote town of Midland City said that they had seen him tirelessly digging up his own yard, even his driveway, sometimes in the middle of the night -- apparently building what one man in the neighborhood described as a bomb shelter fortified by sand.

Dykes burst onto the yellow school bus around 3:40 p.m. on Tuesday, authorities said. When the driver, Charles Albert Poland Jr., 66, tried to stop Dykes from taking children off the bus, he was fatally shot.?The source close to the investigation told NBC News that four spent bullets were found at the scene.

The county school system said that 21 students had made it off the bus safely, and praised Poland as a fallen hero. But the gunman made off with the one child, possibly because the boy fainted during the siege, according to WSFA, an NBC station.

Authorities offered no hints to the gunman?s motive.

Warm tributes were paid to Poland, who had held the job since 2009. Linda Williams, a county tax clerk whose cousin was married to Poland, described him to NBC News as ?a good Christian man? who was active in church.

?It says in the Bible the meek will inherit the earth,? brother-in-law Melvin Skipper told the Dothan Eagle newspaper. ?He was the meekest man I knew.?

Poland?s neighbor, Hilburn Benton, told the newspaper Poland refused to accept payment for work on his yard two years ago. ?He told me, ?You?re my friend and you?re my neighbor. I?m not charging you a dime,?? Benton recalled.

Dykes had been due in court Wednesday morning to face a misdemeanor charge of menacing. A neighbor, James E. Davis Jr., claimed that Dykes had pointed a pistol at his truck on Dec. 10 and fired the weapon.

The Associated Press said Dykes was accused of shooting at his neighbors in a dispute over a speed bump.

Dale County Board of Education

The Dothan Eagle?quoted another neighbor, Michael Creel, describing the bunker as a ?homemade bomb shelter,? roughly 4 feet wide, 6 feet long and 8 feet deep and covered by several feet of sand.

Another neighbor, Danny Dean, told NBC News that he had dug up his own driveway.

Rhonda Wilbur told WSFA that Dykes was a longtime source of concern in the neighborhood because ?he has been like a time bomb waiting for him to go off.? Wilbur told reporters that Dykes had beaten her dog to death with a lead pipe.

A minister, Michael Senn, told WSFA that the other children ran for safety and hid behind Destiny Church.

?All the kids are at a safe place,? he said, though he added that they all appeared to be in shock.

In addition to the county sheriff?s department, the FBI and a SWAT team were on the scene. A woman answering the phone at the Midland Police Department said the FBI had completely taken over and that local police were no longer involved. Authorities ordered people living nearby to leave during the standoff.

Schools in Dale County and the nearby city of Ozark were closed for the rest of the week. Dale County schools said counselors would be available to help students, including those who were on the bus.

NBC staff writers Isolde Raftery and Alastair Jamieson contributed to this report.

The Dothan Eagle via AP

A man boarded this stopped school bus in the town of Midland City on Tuesday afternoon and shot the driver when he refused to let a child off the bus. The bus driver died.

Source: http://usnews.nbcnews.com/_news/2013/01/30/16759153-boy-held-hostage-in-bunker-after-being-snatched-from-school-bus

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Two-step immunotherapy attacks advanced ovarian cancer

Jan. 31, 2013 ? Most ovarian cancer patients are diagnosed with late stage disease that is unresponsive to existing therapies. In a new study, researchers from the Perelman School of Medicine at the University of Pennsylvania School of Medicine show that a two-step personalized immunotherapy treatment -- a dendritic cell vaccine using patients' own tumor followed by adoptive T cell therapy -- triggers anti-tumor immune responses in these type of patients. Four of the six patients treated in the trial responded to the therapy, the investigators report this month in OncoImmunology.

"What we proved in this study is that this is a safe treatment strategy," says co-first author Lana Kandalaft, PharmD, MTR, PhD, research assistant professor of Obstetrics and Gynecology and director of clinical development in the Ovarian Cancer Research Center. "It is a walk in the park for patients, especially compared to standard chemotherapies and surgical treatments for ovarian cancer -- literally, some patients left the clinic and went for a walk in a nearby park after their treatment."

The findings follow research by the study's senior author, George Coukos, MD, PhD, director of the Ovarian Cancer Research Center at Penn, who showed in 2003 that women whose ovarian tumors were infiltrated by healthy immune cells, called T cells, tended to live longer than women whose tumors were devoid of T cells. That observation and other subsequent ones suggest the patient's immune system is trying to fight off the disease but can't quite muster the strength to beat it. Therefore, investigators have been trying to find ways using patients' own tumor cells to boost the immune system's power.

In the current study, Coukos, Kandalaft, co-first author Daniel J. Powell Jr., PhD, research assistant professor of Pathology and Laboratory Medicine, and colleagues treated six women with advanced ovarian cancer in a two-staged immunotherapy protocol in which they utilized a dendritic cell vaccine created from tissue in the patients' own tumor, which was stored at time of surgery. All of these women's cancers had progressed on standard of care chemotherapy.

In the first segment of the study, the team prepared an individualized dendritic cell vaccine for each patient. They harvested dendritic cells from each patient using apheresis, the same process volunteers go through when they donate platelets or other blood products such as those collected for stem cell transplants. Kandalaft and colleagues then exposed each patient's dendritic cells to tumor extract produced from the woman's own tumor, which teaches the dendritic cells who the enemy is. After this priming, the investigators vaccinated each patient with her own dendritic cells and gave them a combination chemotherapy regimen of bevacizumab and cyclophosphamide. Because dendritic cells are like the generals of the immune system, they then induce other immune cells to take up the fight.

Of the six patients who received the dendritic cell vaccine, four developed an anti-tumor immune response, indicating that the approach was working. One of those patients had no measurable disease at study entry because all of it had been successfully removed during surgery. She remains in remission today, 42 months following vaccine treatment. The other three who had an immune response to the vaccine still had residual disease and went on to the second segment of treatment.

The team harvested T cells from each of these three women. Using a technique developed at Penn, they grew the cells in the laboratory, expanding their numbers exponentially, and then reintroduced them into each patient after she underwent a lymphodepleting chemotherapy regimen. Because the T cells had already been trained by the dendritic cell vaccine to attack the tumor cells, the adoptive T cell transfer amplifies the anti-tumor immune response.

Two of the women showed a restored immune response after the T cell transfer. One of the women continued to have stable disease, whereas the other had a complete response to the therapy.

The researchers say it is too early to say whether this type of therapy will be effective in a large number of ovarian cancer patients, but the early results are promising. First, and foremost, she notes, the two-step approach appears safe and well tolerated by the patients. Additionally, the team saw a correlation in both treatment steps between immune responses and clinical benefit, suggesting that it is, in fact, the immune response that is holding the disease in check.

With these encouraging results in hand, the team has opened a larger trial in which they have already enrolled about 25 women and aim for up to 30 more. The new protocol uses an improved vaccine platform and an optimized adoptive T cell transfer protocol. The PI of this study is Janos Tanyi, MD, PhD.

"Large clinical trials have shown that intensifying chemotherapy doesn't improve outcomes for women with advanced ovarian cancer," Coukos says. "So we need to explore other avenues. We think the combinatorial approach of both immune and chemotherapy is the way to go."

Other co-authors from Penn include Cheryl L. Chiang, Janos Tanyi, Sarah Kim, Kathy Montone, Rosemarie Mick, Bruce L. Levine, Drew A. Torigian, and Carl H. June. Co-author Marnix Bosch is from Northwest Biotherapeutics in Bethesda, MD.

This study was supported by National Cancer Institute Ovarian SPORE grant P01-CA83638, National Institution of Health R01FD003520-02, and the Ovarian Cancer Immunotherapy Initiative.

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Story Source:

The above story is reprinted from materials provided by University of Pennsylvania School of Medicine.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Lana E. Kandalaft, Daniel J. Powell, Cheryl L. Chiang, Janos Tanyi, Sarah Kim, Marnix Bosch, Kathy Montone, Rosemarie Mick, Bruce L. Levine, Drew A. Torigian, Carl H. June and George Coukos. Autologous lysate-pulsed dendritic cell vaccination followed by adoptive transfer of vaccine-primed ex vivo co-stimulated T cells in recurrent ovarian cancer. OncoImmunology, 2013; 2: e22664 [link]

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/e4YY26wgzQU/130131163017.htm

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Did Google make its latest Android statue out of chrome for a reason?

Did Google make its latest Android statue out of chrome for a reason

When Google staffer Paul Wilcox started throwing pebbles at his girlfriend's office window, he never expected to be confronted by an angry giant Android made out of chrome. But crazy things happen at Mountain View all the time and Wilcox was quick to recover his composure.

"What have you done with my girlfriend?" he cried. And then, "why, of all things, are you made out of chrome?!"

Eventually Wilcox realized it was just a statue, recently put up in the mostly-green robot's honor, and that his girlfriend was safe and well. (Honestly, we just invented the whole girlfriend thing for dramatic effect, and we don't know where she works.) Anyways, the question remains: why this particular metallic finish? Is it to mark the constant updates to the Chrome browser on Android devices? Possibly. Or could it be, as MobileGeeks suggests, some oblique reference to Android apps running in a Chrome browser on some other OS? We don't know, but imagine this: an Android app running in a Chrome browser running as an Android app running in a Chrome browser... Freaky, right?

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Comments

Via: MobileGeeks (German)

Source: Paul Wilcox (Google+)

Source: http://www.engadget.com/2013/01/31/google-chrome-android-statue/

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